The daughter-in-law (II-2) had normal thyroid function but positive for autoantibodies for thyroid disease as follows: TSH 2.78 mIU/L, fT4 0.99 ng/dL, T3 112.50 ng/dL, Tg antibody 55.7 IU/mL, TPO antibody 294.2 IU/mL, and TSH-receptor antibody 2.5 IU/L. The gene discussed is TPO; the disease is thyroid gland disorder.