SOD1 and amyotrophic lateral sclerosis: We reprogrammed fibroblasts from two sporadic ALS patients (sALS n = 2), two familial ALS cases with SOD1 mutations (fALS n = 2) and two healthy subjects as controls (CTRL n = 2) into iPSCs (Supplementary Table S1) using a non-integrating reprogramming protocol based on Sendai virus technology31,32.