We thus assayed, for quantitative Real Time PCR analysis (qRT-PCR) in ALS and CTRL-MN progenitors, Tumor protein p53 (TP53), MDM2 proto-oncogene (MDM2), and X-linked inhibitor of apoptosis (XIAP), associated with oxidative stress-induced senescence and apoptosis; Syntaxin 1A (STX1A) and Synaptotagmin 1 (SYT1), which are involved in synaptic vesicle trafficking; Sirtuin 1 (SIRT1), a specific is target of miR-34a28 (Supplementary Table S2). The gene discussed is SIRT1; the disease is amyotrophic lateral sclerosis.