To test whether miR-130a and miR-145 could decrease TβRII expression in myeloid cells and inhibit tumor metastasis in vivo, miR-130a and miR-145 were subcloned into a pFUGW lentiviral expression vector under control of the CD11b promoter, with or without a GFP reporter (Fig. 2a; upper panel). The gene discussed is ITGAM; the disease is neoplasm.