Five of the pan-cancer ALFRED genes (BRCA1, ATM, BRCA2, NSD1, and TPCN2) were individually significantly enriched for RDGVs in cases versus controls (P < 0.05 by pan-cancer case-control analysis, Fig. 3c) with one additional gene, NIPAL3, marginally significant (P = 0.07 by case-control analysis) (Fig. 3c). This evidence concerns the gene TPCN2 and cancer.