At an FDR = 0.2, four genes previously reported as somatic cancer genes were significantly enriched for AI in samples with RDGVs in the pan-cancer analysis (OR = 5.1, Fisher’s exact test P = 2.1 × 10−2; Fig. 2c): MYH1 (RR = 2.3, 25.3% versus 12.6%, P < 2.0 × 10−6), NOP56 (RR = 4.6, 50% versus 17.8%, P < 2.12 × 10−4), NSD1 (RR = 2.0, 22.2% versus 12.4%, P < 2.56 × 10−4), and PRPF8 (RR = 3.2, 57.1% versus 29.1%, P < 7.76 × 10−4). This evidence concerns the gene PRPF8 and cancer.