NSD1 and cancer: However, the variants in NSD1 enriched in cancer patients are distinct from the variants that cause Sotos syndrome (Supplementary Fig. 12h) and they are much less likely to be truncation variants (OR = 151.8, Fisher’s exact test P < 2.1 × 10−40), suggesting different mechanisms or allele-strengths underlie cancer predisposition and Sotos syndrome.