In addition, three of the six individual cancer type ALFRED genes were enriched for RDGVs in cases of the matched cancer type versus controls (P < 0.05, Fig. 3d; Supplementary Data 6): BRCA1 and BRCA2 in breast invasive carcinoma (BRCA) and OV, and ATM in BRCA. The gene discussed is BRCA1; the disease is invasive breast carcinoma.