Furthermore, we also used a PTV-ALFRED model to analyze each of the 17 cancer types and three genes were significant in at least one individual cancer type (FDR = 0.2, four associations: BRCA2 and ATM in breast cancer, BRCA1 and BRCA2 in ovarian cancer) (Supplementary Fig. 8e and g). This evidence concerns the gene BRCA1 and cancer.