Eight of the 13 ALFRED genes with a nominally significant association between RDGVs and AI in at least one cancer type in the ALFRED analysis (P < 0.05; Fig. 2d and Supplementary Data 5) also had an enrichment of RDGVs in a matched cancer type compared to in controls (P < 0.05, Fig. 3d; Supplementary Data 6): ATM in colon and rectum adenocarcinoma (COADREAD), lung adenocarcinoma (LUAD) and in PRAD, NSD1 in OV, and TPCN2 in uterine corpus endometrial carcinoma (UCEC). The gene discussed is NSD1; the disease is cancer.