COL18A1 and neoplasm: On the other hand, genistein also up-regulated the expression of three potent anti-angiogenic molecules, i.e., TIMP-2, -3 (both tumor suppressor genes), and COL18A1 (proteolytic processing at several endogenous cleavage sites in its C-terminal domain results in production of endostatin, a potent anti-angiogenic protein) [35].