TRPC6 influences endothelial apoptosis in an experimental model of atherosclerosis [148] and we observed that polymorphic gene variants of TRPC6 associate with susceptibility to apoptosis of peripheral blood mononuclear cells and diverging responses to the pharmacological inhibition of the channel in patients with SLE [84]. The gene discussed is TRPC6; the disease is systemic lupus erythematosus.