TNFRSF1B and inflammation: Interestingly, even if TNFR1 KO mice displayed amounts of IFN-γ 13-fold higher than WT, this was significantly lower than TNF KO and TNFR1R2 KO mice (Figure 4a), indicating a role for both TNFR1 and TNFR2 in BCG induce pleural inflammation.