The enriched pathways for the downregulated genes included the JAK-STAT signalling pathway, natural killer cell-mediated cytotoxicity, MAPK signalling pathway, ErbB signalling pathway, pathways for several cancers, type II diabetes mellitus, Toll-like receptor signalling pathway, chemokine signalling pathway, GnRH signalling pathway, Fc gamma R-mediated phagocytosis, apoptosis, p53 signalling pathway, Wnt signalling pathway and insect hormone biosynthesis (figure 7c). The gene discussed is TP53; the disease is type 2 diabetes mellitus.