Obesity is associated with reduced capacity or compromised mitochondrial oxidation in adipose tissue and the ability of TZDs to restore these defects is likely to be important for insulin sensitization, possibly through the improvement of systemic lipid metabolism (Wilson‐Fritch et al, 2004; Rong et al, 2007; Soccio et al, 2017). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.