In contrast, differentially expressed transcripts detected in sporadic ALS were associated with functions in the mitochondrial respiratory chain complex assembly (p = 8.53*10− 21) and related terms (Fig. 1f), and included 9 members of the NADH dehydrogenase (complex I) enzyme and 6 components of cytochrome oxidase C (complex IV) (Additional file 6: Figure S2A). Here, ENSG00000251605 is linked to amyotrophic lateral sclerosis.