APOE and dementia: Nonetheless, again as reported previously [18, 41, 43, 51], age at death was earlier in ε4 allele bearers than in those without ε4 allele and was later in ε2 allele bearers than in those without ε2 allele suggesting that possession of APOE ε4 allele may hasten the onset of dementia and mortality by promoting an earlier formation, or a more rapid accumulation, of plaques and tangles.