The reduced myofiber size in ΔKlotho mice at an age of p56 concomitant with the increased expression of the ubiquitin ligases (MuRF1-3 and Fbxo32/Atrogin/MAFbx) in muscles from ΔKlotho mice suggest that ΔKlotho mice display an age-dependent reduction in muscle mass, which is reminiscent of sarcopenia. This evidence concerns the gene FBXO32 and sarcopenia.