Specifically, TLR8 ligands, such as third-generation polyamidoamine dendrimers (poly-G3) and ssRNA40, were shown to enhance antitumor immunity by modulation of endogenous cAMP in tumor cells through the activation of the protein kinase A (PKA) type I–COOH-terminal Src kinase (Csk)–LCK inhibitory pathway [94]. This evidence concerns the gene TLR8 and neoplasm.