By using the FGFR4 inhibitor BLU9931, a robust reduction in the major components of Wnt/β-catenin and decreased migratory ability of HCC cells was found, indicating the FGF15/FGFR4-dependent activation of EMT and Wnt/β-catenin signaling. Here, FGFR4 is linked to hepatocellular carcinoma.