Consequently, the important components (FGFR4, FASN, AFP and β-catenin) related to lipid metabolic disorder, liver injury and CSC initiated the HCC transformation found in the animal studies; these were further evaluated by Western blot in the paired human samplers (tumor and benign) of 33 NASH-HCC patients. Here, FGFR4 is linked to metabolic dysfunction-associated steatohepatitis.