NEDD9 and rheumatoid arthritis: Miyake-Nishijima et al. [35] demonstrated the overexpression of Cas-L protein and the increase of its tyrosine phosphorylation in RA mouse model, as well as observed a large number of Cas-L-positive lymphocytes infiltrating to the inflammatory lesions of RA patients, implying the important roles of Cas-L in the pathophysiology of RA.