Considering their significantly differential expression patterns, great network topological importance and functional relevance to RA, we selected MX1, OASL, SPINK1, CRK, GRAPL and RNF2 as the candidate gene biomarkers and their expression levels in peripheral blood would be used to construct the PLS-based model for predicting the response to TG tablets. Here, GRAPL is linked to rheumatoid arthritis.