We decided to conduct all subsequent experiments using the A2780CP ovarian cancer cell line as well as the ECC-1 endometrial cancer cell lines as they, respectively, are highly relevant models to both classical manifestation of these cancers; A2780CP is an epithelial, hormone independent, robustly cisplatin-resistant cell line presenting p53 mutations; on the other hand, ECC-1 is an epithelial, hormone responsive, mildly cisplatin-resistant cell line presenting PI3K/Akt amplifications and PTEN deletion. This evidence concerns the gene PTEN and ovarian cancer.