The delicate balance between functional receptors and decoy receptors is also a fundamentally intricate equilibrium, a complexity that allows the exquisite specificity of TRAIL to arise in normal tissues; interestingly, the regulation of decoy receptor expression influence on TRAIL sensitivity is not only limited to the expressing cells but also key to the tumor microenvironment, and thus, general tumor susceptibility to this process of cell suicide [64]. The gene discussed is TNFSF10; the disease is neoplasm.