Studying the synergistic effect of CETP B1, NOS3 T and ANGPTL8 T alleles on the risk of CVD and T2DM showed that the concomitant presence of CETP B1 and NOS3 T allele, was associated with 8.36-fold increased risk of T2DM (p < 0.0001), 6.33-fold increased risk of CVD (p = 0.0002) and 7.87-fold increased risk of CVD in T2DM patients (p = 0.006). Here, ANGPTL8 is linked to type 2 diabetes mellitus.