NOS3 and type 2 diabetes mellitus: For NOS3 G894T (rs1799983), the frequency of the variant allele (T) was significantly higher in T2DM patients than in control subjects (21.4% vs. 8%, p < 0.0001) and associated with 3.07-times increased risk to develop T2DM (95% CI 1.82–5.19) (Table 2).