NOS1 and Abnormal renal physiology: G894T polymorphism in the NOS3 gene, which is associated with reduced NOS enzyme activity and consequently bioavailability of NO, has been associated with diabetes and diabetes related traits [35, 36], as well as relevant sub-clinical cardiac remodeling in CKD (chronic kidney disease) and has been reported as an important genetic biomarker in non-dialysis CKD patients who are at risk of worsening cardiac disease with progression of renal dysfunction [37].