NOS3 and type 2 diabetes mellitus: Meanwhile, concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles together elevated the risk of T2DM by 13.22-fold (p = 0.004) and CVD risk by 8.86-fold (p = 0.03) and highly elevated the risk of CVD in T2DM patients by 13.8-fold (p = 0.008) (Table 7).