Our results showed that NOS3 rs1799983, ANGPTL8 rs2278426 and CETP rs708272 variants associated with increased risk of T2DM by 3.07-, 2.33- and 1.75-fold, respectively, while only NOS3 variant associated with 3.08-fold increased risk of CVD. This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.