ANGPTL8 and type 2 diabetes mellitus: For ANGPTL8 c194C>T (rs2278426), the frequency of the variant allele (T) was significantly higher in T2DM patients than in control subjects (16% vs. 7.4%, p = 0.001) and was associated with 2.33-times increased risk of T2DM (95% CI 1.33–4.08) (Table 2).