PKD1 and autosomal dominant polycystic kidney disease: Pronounced genic effects upon the clinical manifestation of ADPKD (early onset) have been observed in cases of contiguous deletion of PKD1 and TSC2 (OMIM *191092), in cases of mosaicism, and/or in cases of bilineal inheritance of a pathogenic PKD1 and PKD2 variant [18–20].