In this study, we aim to explore the expression pattern and clinicopathological significance of SPARCL1 in a Chinese gastric GIST cohort, as well as to investigate whether the downregulation of SPARCL1 can enhance the invasion/migration ability of GIST cells in vitro or facilitate liver metastasis of GIST cells in vivo. This evidence concerns the gene SPARCL1 and gastrointestinal stromal tumor.