Some of these polymorphisms, including VEGF –2578A/C (rs699947), −1154G/A (rs1570360), +405C/G (rs2010963), and + 936C/T (rs3025039), which arise from the vascular expression of different VEGF proteins, have been associated with CAD susceptibility; however, these findings are controversial. The gene discussed is VEGFA; the disease is coronary artery disorder.