SERPINE1 and heart failure: PAI-1 activity rise correlated with heart failure occurrence (rpb = 0.393, P < 0.001), thrombus aspiration (rpb = 0.344, P = 0.001), pulmonary edema (rpb = 0.267, P = 0.012), and final TIMI flow lower than 3 (rpb = 0.235, P = 0.029).