However, as early as 5 days after infection, the DbNP366 and DbPA224‐specific T cells significantly outnumber the KbNS2114 and DbPB1‐F262‐specific T cells, indicating that precursory frequency is not the sole determinant of the magnitude of the CD8+ T‐cell response.18, 19 Further experiments demonstrated that the capacity of the T cells to proliferate following IAV infection and the avidity of the TCR for antigen also contribute to the magnitude of the CD8+ T‐cell response. Here, CD8A is linked to infection.