SLC7A2 and cancer: For example, expression of inducible nitric oxide synthase and arginase I is regulated by Th1 and Th2 cytokines, respectively.66 Macrophages activated by the Th2 cytokines IL‐4 and IL‐13 highly express arginine transporter SLC7A2 (also named CAT2) and arginase I and induce depletion of arginine from their local environment.67 This change in local arginine concentration ultimately decreases CD3ζ expression in activated T cells and diminishes their proliferation.67 The same deprivation can be observed in several types of cancers with a similar effect on T‐cell immunity.