FNDC5 and heart failure: In patients with heart failure withreduced ejection fraction, muscle, fat and bone loss were reported to be associatedwith worse outcomes.30 Moreover, arecent study reported a gradual decrease in irisin levels in patients with acute MI,suggesting that irisin may be a new diagnostic marker in this setting.31 In a recently published study,Shen et al.32 have reported that serum irisin level was significantly higher indeceased acute heart failure (AHF) patients compared to that in survived AHF andpredicted 1-year all-cause mortality in AHF patients.