By elevating eNOS, adropin may have the potential to improve endothelial dysfunction,which has been widely reported in patients with heart failure with reduced ejectionfraction, and decelerate left ventricular dysfunction in heart failure with reducedejection fraction.28 Lian etal.7 have reported that anelevated level of adropin in heart failure with reduced ejection fraction wascorrelated with the severity of heart failure with reduced ejection fractionaccording to the NYHA class and BNP levels. This evidence concerns the gene NOS3 and endothelial dysfunction.