Mechanical stretch‐induced activation of matrix metalloproteinases in neonatal rat cardiomyocytes is mediated by Ang II‐JAK‐STAT pathway.38 JAK‐STAT signalling has been implicated in pressure overload‐induced cardiac hypertrophy and remodelling.12 Ang II promotes the activation of JAK/STAT and expression of ANP in atrial myocytes.1 In the present study, in vitro knockdown of JAK2 with specific siRNA attenuated the elevated expression of p‐STAT3, ANP and Troponin T induced by TWEAK. This evidence concerns the gene STAT3 and cardiac hypertrophy.