AFAP1‐AS1 has also been implicated in a number of other cancers, including hepatocellular carcinoma,26 lung cancer27 and nasopharyngeal carcinoma.28 In this study, we have been suggested that AFAP1‐AS1 promotes oncogenesis in laryngeal carcinoma by enhancing cancer cell stemness and chemoresistance. Here, AFAP1 is linked to laryngeal carcinoma.