NOTCH1 and head and neck squamous cell carcinoma: RBPJ plays a crucial role in the notch signalling pathway, including as a primary transcriptional effector and potentially as a maintainer of gene expression programs.45, 46 When associated with Notch proteins, RBPJ acts as a transcriptional activator, but when not associated with Notch proteins, it exists in complexes with corepressors and serves to block transcription.47 Even though there are no studies that link RBPJ activity to laryngeal carcinoma, in 2016, Liu et al48 found that somatic mutations in NOTCH1 correlated strongly with higher rates of recurrence and lower survival in HNSCC.