Up to now, emerging published literatures have indicated the important function of long non‐coding RNAs (lncRNAs) in the chemoresistance of multiple tumours.9, 19, 20 For example, lncRNA RP11‐770J1.3 and TMEM25 were highly expressed in paclitaxel‐resistant human breast cancer cells (MCF‐7/PR), while their down‐regulated expression enhanced the sensitivity of MCF‐7/PR cells to paclitaxel and inhibited the expression of MRP, BCRP and MDR1/P‐gp.21 Our research team identifies the overexpression of lncRNA FTH1P3 in paclitaxel‐resistant breast cancer tissue and cell lines. Here, TMEM25 is linked to breast cancer.