ABCB1 (P‐glycoprotein) is one of most canonical chemoresistance protein that involving multiple drug resistance in cancer.27, 28 Our results reveal that FTH1P3 might promote ABCB1 protein expression through sponging mmiR‐206 and subsequently activates the paclitaxel resistance in breast cancer. The gene discussed is FTH1P3; the disease is breast cancer.