GZMB and colorectal carcinoma: Similarly, another group investigated the impact of DHA on migration in CRC cell lines and reported that 100 μM DHA could inhibit Granzyme B expression in three human CRC cell lines (HCT116, CSC4, and HT-8), thus reducing their ability to undergo epithelial-mesenchymal transition (EMT) and invade matrigel [18].