IGHE and asthma: SAFS is defined as severe, therapy-resistant asthma with fungal sensitization demonstrated by a positive skin prick test response or specific IgE to at least one of 7 fungi (i.e., Aspergillus fumigatus, Alternaria alternata, Cladosporium herbarum, Penicillium chrysogenum, Candida albicans, Trichophyton mentagrophytes, or Botrytis cinerea), with IgE <1,000 and with negative IgG Aspergillus serology (102).