GNAS and obesity due to melanocortin 4 receptor deficiency: Meng et al. (2017) reported that this gene is significantly associated with ADG in a Yorkshire pig and may be involved in pig growth and development. The GNAS gene is near SNP WU_10.2_17_66292358. The imprinted GNAS is involved in obesity, energy metabolism, feeding behavior, and viability. Eaton et al. (2012) reported that mutations in this gene can lead to pre-weaning growth retardation and incomplete catch-up growth in mice.