MEGF11 and Global developmental delay: Takasu et al. (2002) reported that EFNB2 protein, which is associated with FCR, is localized at excitatory synapses, regulating the development and remodeling of neural signals. MEGF11, another gene associated with FCR, is highly expressed in the central nervous system, whose homology MEGF10 in Drosophila plays an important role in maintaining the normal functioning of the brain (Draper et al., 2014). Finally, LRFN5, also a FCR associated gene, is a key neurodevelopmental gene that is associated with developmental delay (Mikhail et al., 2011).