FMR1 and fragile X-associated tremor/ataxia syndrome: Bearing in mind that FMRpolyG and FMRP are generated from the same transcript, albeit in different reading frames, and that production of FMRpolyG as well as abrogation of FMRP expression results in pathology has important implications and should be taken in mind while designing a successful therapeutic approach against FXTAS (Yang et al., 2015).