OPTN and amyotrophic lateral sclerosis: Indeed, Optn has been detected in distinct types of ALS intraneuronal inclusions, in neurofibrillary tangles and dystrophic neurites in Alzheimer’s disease, in Lewy bodies and Lewy neurites in Parkinson’s disease, ballooned neurons in Creutzfeldt–Jakob’s disease, glial cytoplasmic inclusions in multiple system atrophy, and Pick bodies in Pick’s disease (149).