OPTN and amyotrophic lateral sclerosis: These genetic forms have made it possible to highlight factors involved in the disease etiology, such as the SOD1 gene that accounts for around 20% of familial ALS cases, TDP-43 and FUS, as well as p97/valosin-containing protein (VCP), UBQLN2, p62/SQSTM1, and Optn (145, 146, 197–199).