The current nomenclature refers to PARK as the chromosomal regions associated with Parkinson’s disease and over six genes have been formally associated with familial Parkinson diseases including PARK1-4 (SNCA; α-synuclein), PARK8 (leucine-rich repeat kinase enzyme) capable of transferring a phosphate group from one molecule to another to regulate its activity, PARK2 (Parkin), PARK6 (PINK1), PARK7 (DJ-1), PARK9 (ATP13A2), and also glucocerebrosidase, PARK17 (VPS35), PARK18 (EIF4G1), and PARK16 (230). This evidence concerns the gene VPS35 and Parkinson disease.