In an acute myeloid leukemia cell line Kasumi-1, Sema4D binding of CD72, its preferred receptor in immune cells, leads to inhibition of growth and cell death, as a result of phosphorylation of CD72, the formation of the CD72–SHP-1 complex and dephosphorylation of src family kinases and JNK (15). This evidence concerns the gene CD72 and acute myeloid leukemia.