IFNAR2 and experimental autoimmune encephalomyelitis: In fact, mice overexpressing IFNAR2 have been reported to be more sensitive to septic shock due to the enhanced IFNAR1 signaling (65), and administration of recombinant IFNAR2 in chronic-progressive Experimental Autoimmune Encephalomyelitis enhances IFN-β signaling, in this case reducing the severity of the disease (66).