Type-I IFNs have been shown to be involved in the pathogenic cascades of neurodegenerative diseases, whereby IFN-α contributes to the appearance of amyloid-related cognitive deficits in animal models of Alzheimer's Disease (18) and deletion of the Ifnar gene has been shown to ameliorate cognitive deficits and attenuate microgliosis. The gene discussed is IFNAR1; the disease is Cognitive impairment.