IFNA1 and Cognitive impairment: Type-I IFNs have been shown to be involved in the pathogenic cascades of neurodegenerative diseases, whereby IFN-α contributes to the appearance of amyloid-related cognitive deficits in animal models of Alzheimer's Disease (18) and deletion of the Ifnar gene has been shown to ameliorate cognitive deficits and attenuate microgliosis.