According to data from the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) Registry, the prevalence of anticentromere (ACA) and nucleolar antibodies (NUC), in SSc-PAH as compared to SSc without PAH, was elevated (35–37 and 24%, respectively) but not the prevalence of Scl-70 (7%) and U1RNP (5%) antibodies. The gene discussed is NUCB1; the disease is pulmonary arterial hypertension.