Gao et al. (2016) thought that hyperglycemia could result in the activation of PARP which competitively utilized the same cofactor (NAD+) with sirt3. Hence, hyperglycemia-induced PARP activation was thought to be one of the reasons that caused the downregulation of sirt3 (Gao et al., 2016). The gene discussed is SIRT3; the disease is Hyperglycemia.