SQSTM1 and ischemia: A previous study demonstrated that the autophagy-related proteins microtubule-associated proteins light chain 3 (LC3B) and sequestosome 1 (SQSTM1, p62) were significantly upregulated in penumbra neurons after focal cerebral ischemia (Rami and Kogel, 2008), whether ischemia-induced autophagy was beneficial or detrimental (Kubota et al., 2010).