In contrast, SOX17 knockdown induced the Ki67 staining and IRS of tumor tissues weaker and lower, respectively, (Fig. 3a–c; 6.67 ± 2.73 vs. 2.33 ± 0.82, p < 0.01, 1.80 ± 1.48 vs. 6.00 ± 3.58, p < 0.05). This evidence concerns the gene SOX17 and neoplasm.