In our study, we utilized two bioinformatics algorithms-TargetScan and PicTar to search for the potential targets and finally identify three targets of miR-133b: c-MET, Sox9, and WAVE2. In the colorectal cancer, c-MET as one target of miR-133b has been reported to participate in cell proliferation and apoptosis27. This evidence concerns the gene SOX9 and colorectal cancer.