In addition, SNHG1 bound to the histone methyltransferase enhancer of the zeste homolog 2 (EZH2, which is a catalytic subunit of polycomb repressive complex 2 (PRC2), an extremely conserved protein complex regulating gene expression with the help of methylating lysine 27 on histone H3), followed by epigenetically suppressing CDKN1A (an inhibitor of the cyclin-dependent kinase, in addition to being a tumor-suppressive gene, which is used in treatment of several cancers22–24) expression in CCA cells, and, as a result, altered the CCA cell biology. The gene discussed is EZH2; the disease is cholangiocarcinoma.