To summarize, we shed light on one of the coregulating genes by SNHG1 as well as EZH2 in CCA, CDKN1A, based on the report that the hypermethylation of the CDKN1A promoter region contributed to CDKN1A transcription inactivation in breast cancer28. The gene discussed is CDKN1A; the disease is cholangiocarcinoma.