MTDH and Parkinson disease: Recently, an excellent paper has been published in Cell Death and Disease by Leem et al. 2018,1 who found that “the sustained level of astrocyte elevated gene-1 (AEG-1) as an important anti-apoptotic factor in nigral DA neurons might potentiate the therapeutic effects of treatments, such as Rheb(S16H) administration, on the degeneration of the dopamine (DA) pathway that characterizes PD”1.