TP53 and colon carcinoma: Furthermore, we observed that P53-proficient HCT116 colon carcinoma cells were also highly sensitive to the (lovastatin + docetaxel) combination, indicating that the apoptosis-inducing capacity of these drugs may not require either active P53 proteins or, possibly, induction of some of their targets (e.g. pro-apoptotic Bcl-2 family members).