MT1-MMP is a membrane-anchored matrix metalloprotease that plays a particularly significant, nonredundant role in the invasion of a range of cancer cell types [83], and while the leading protrusion of invasive cancer cells may have the capacity to recruit and align ECM fibres (without large-scale degradation), an integrin and actin-rich zone of collagen degradation posterior to this (in front of the nucleus) has been described [84]. This evidence concerns the gene MMP14 and cancer.