AKT1 and cancer: Filopodia can also support invasive migration of cancer cells; the local co-trafficking of α5β1 and receptor tyrosine kinases (RTKs, including epidermal growth factor receptor 1) facilitates crosstalk between adhesion receptors and RTKs [80] and supresses Rac activity, but activates RhoA at the leading edge to generate actin-spike protrusions at the front of invading carcinoma cells [81].