A range of autoimmune CNS diseases involving neuronal destruction is likely mediated by CD8+ T cells, as suggested by the presence of CD8+ T cells in affected brain areas in Rasmussen’s encephalitis [10], paraneoplastic neuronal degeneration [11], and Multiple Sclerosis [12] which is otherwise considered a CD4+ T cell driven disease. The gene discussed is CD8A; the disease is multiple sclerosis.