With a high availability of pathological factors, such as resection status (97.4%) ECE (99.0%), LI (90.7%), VI (90.7%) and HPV-p16-status (77.2% of all tumors; 84% of oropharyngeal tumors), a long-time follow-up (median 45 months) and well documented events (26 local, 33 locoregional, 39 distant recurrences and 97 deaths) our study provides valid data for extensive statistical analysis. This evidence concerns the gene CDKN2A and neoplasm of oropharynx.