Previously described risk factors, such as large primary tumors (pT3 or pT4) the presence of positive lymph nodes with and without extranodal disease (ECE), positive resection margins (R1), lymphangiosis (LVI), perineural invasion (PNI) and positive prognostic factors such as HPV-p16-positive oropharyngeal carcinoma (HPVOPC) were analyzed for correlation with local control, locoregional control, distant control, any control, overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) in univariate and multivariate cox regression analysis (see Table 2, Fig. 2a-d). The gene discussed is CDKN2A; the disease is oropharyngeal carcinoma.