Numerous variants in RYR1 have been identified as the cause of RYR1-RM subtypes, including central core disease (CCD), multi-mini core disease (MmD), centronuclear myopathy (CNM), core-rod myopathy, and congenital fiber type disproportion (CFTD). This evidence concerns the gene RYR1 and autosomal dominant centronuclear myopathy.