Furthermore, we previously reported that TILs from pancreatic tumor as well as GBM tissue can be successfully expanded in culture medium containing IL-2, IL-15 and IL-21, leading to proliferation of central memory T cells with strong effector functions and a rich TCRVβ repertoire, hinting at a wide epitope recognition potential [29, 30]. This evidence concerns the gene IL21 and pancreatic neoplasm.