Specifically, patients with GBM presented the lowest IFNγ increase production to CMV-pp65 and EBNA-1 (ΔIFNγ production median respectively only + 200 and + 291.2 pg/ml) that were significantly lower that the patients with pancreatic cancer (p < 0.001, ΔIFNγ production median up to + 2800 pg/ml, Fig. 3 c, d). The gene discussed is IFNG; the disease is familial pancreatic carcinoma.