Interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα) production by CD4+ T helper 1 (Th1) targeting EBV nuclear antigen 1 (EBNA-1) in patients with breast cancer harboring the latent form of EBV correlated with better clinical outcome compared to those infected with the replicative form of the virus [9]. This evidence concerns the gene TNF and breast cancer.