Regarding the response to viral antigens EBNA-1 and CMV-pp65, patients with brain tumor [GBM, OA/OD, astrocytoma (A) and brain metastasis (M)] produced significantly less IFNγ as compared to patients with pancreatic cancer as well as HD (p < 0.001, Fig. 2 a, b). This evidence concerns the gene IFNG and familial pancreatic carcinoma.