NME1 and melanoma: At almost the same time, Jarrett et al. reported that human melanoma cell lines with coordinately low expression of Nm23-H1 and Nm23-H2 repaired UV-induced 6–4 photoproducts and other DNA polymerase-blocking lesions at a slower rate, and that the kinetics of repair were accelerated significantly upon forced expression of Nm23-H1, through enhanced NER [7].