ERBB2 and cervical carcinoma: Next, also based on our previous results where we observed an elevated expression of HER2 in C33A, a cervical cancer cell line harboring the p53R273C mutant; we silenced the endogenous expression of the p53R273C mutant in C33A cell line, and this silencing lead to a decreased in the expression in both mRNA and protein levels of HER2 as well as in the case of p53R248Q mutant (Fig. 2e and f).