Next, also based on our previous results where we observed an elevated expression of HER2 in C33A, a cervical cancer cell line harboring the p53R273C mutant; we silenced the endogenous expression of the p53R273C mutant in C33A cell line, and this silencing lead to a decreased in the expression in both mRNA and protein levels of HER2 as well as in the case of p53R248Q mutant (Fig. 2e and f). This evidence concerns the gene ERBB2 and cervical cancer.