BRAF and melanoma: For instance, in a study reported by Simeone et al. patients with BRAF-mutated melanoma previously treated with BRAFi had a significantly lower median PFS (3 months vs. not reached) and DCR (18.6% vs. 65.4%) to pembrolizumab compared to wild-type melanoma treated with anti-PD-1 after ipilimumab escape [10].