Before anti-PD-1 first administration, poor PS (≥1: 80.5% vs. 39.4%, p < 0.001), brain metastasis (61.0% vs. 18.2%, p < 0.001), and important tumor burden (> 3 metastatic sites: 48.8% vs. 24.2%; p = 0.04) were significantly higher in BRAF-mutated patients (Table 1). Here, BRAF is linked to neoplasm.